Traditional open surgical approaches to excise cystic neoplasms of the pancreas may be associated with significant morbidity. Minimally invasive approaches are still in evolution but may prove beneficial. We present a video that documents a laparoscopic distal pancreatectomy with splenectomy. Our patient is a 51 year old Caucasian woman who was found to have an incidental 3 cm cystic lesion in the tail of the pancreas on CT scan of the abdomen during an evaluation for diverticulitis. Utilizing a laparoscopic four-port technique, the lesser sac was entered and the left lobe of the liver and stomach were elevated using a Nathanson liver retractor. Intraoperative ultrasound of the pancreas was used to verify the location of the neoplasm. The pancreas was divided to the left of the superior mesenteric vessels with a linear stapler including the splenic vessels and the distal pancreas and spleen were removed en-bloc. The patient was discharged home on postoperative day number four and pathology revealing a pancreatic microcystic adenoma. Laparoscopic distal pancreatectomy is an effective minimally invasive technique for treating pancreatic cystic neoplasms. Moreover, the medial approach with en-bloc vascular ligation simplifies this procedure and further minimizes.