An innovative mininvasive robotic operation was performed on a female aged 28 affected by a pancreatic insulinoma. CT and MR revealed the presence of a 19mm nodule of the pancreatic tail, suspect for being a neuroendocrine tumor. In a few cases (< 10%) these neoplasms can be multiple. A new intra-operatory nuclear technique was used, based on a combination of a small laparoscopic probe (expressly created for radioguided surgery) and a pre-operatory scintigraphy; the probe was introduced into the abdominal cavity to detect the pancreatic tumor that, expressing somatostatin receptors, could concentrate the somatostatin analogue 111-In octreotide previously injected. The operation was entirely performed by a mininvasive robotic technique. The radionuclide scan identified two areas of 111-In uptake within the pancreas: one in the tail (the lesion evidenced by CT), and the other in the pancreatic head, otherwise undetected by the other imaging techniques. A a four arms surgical robot (Da Vinci-Intuitive)was used; both nodules were laparoscopically removed sparing the rest of the pancreas. The histological examination confirmed the benign endocrine nature of the tumor with prompt normalization of the glucidic metabolism and the various biochemical markers. The post-operative course was uneventful and the patient discharged at day 5th in normal conditions.