Introduction: Laparoscopic cholecystectomy during late pregnancy could be challenging. Indocyanine Green (ICG) dye is an excellent medium for biliary tree imaging as following its intravenous injection, it is selectively taken up by hepatocytes and excreted into the bile. We herein presenting a 36 weeks pregnant female who underwent laparoscopic cholecystectomy with intraoperative Indocyanine Green Fluorescence Cholangiography (ICG) with a positive outcome. Presentation: A 28 years old female, 36 weeks pregnant, Gravida 4 Para 3. She is 82.72 kg, BMI 31.2. She presented to the ED with severe right upper quadrant pain and tenderness after eating. She was afebrile, stable vital signs with WBC 17.0 with left shift. Right upper quadrant US showed cholelithiasis with layering calcified gallstones and sludge. Procedure: Several operative strategies for laparoscopic approach during pregnancy are illustrated including partial left lateral decubitus position to minimize compression of the IVC, intraoperative SCD for DVT prophylaxis and perioperative fetal monitoring as per obstetric team. Technical considerations including: Open Hassan for a safe Initial abdominal access, Location of trocars should be adjusted according to fundal height and low CO₂ pneumoperitoneum of 10-15 mmHg. The ICG using pinpoint technology clearly visualized the ductal anatomy.Postoperatively, the patient did well. She went home on POD# 2 Conclusion: In expert hands, laparoscopic cholecystectomy is a safe and feasible approach during late pregnancy. Indocyanine Green Fluorescence Cholangiography (ICG) adds an additional safety feature in such a challenging procedure by delineating the biliary ductal anatomy and minimizing the risk of bile ducts injury.