Introduction: The resection of infected prosthetic mesh after open ventral hernia repair is a challenging surgical dilemma. Open component separation can result in major wound morbidity. We present a novel endoscopic component separation performed during the resection of a piece of infected prosthetic mesh.

Methods: Technical aspects of an endoscopic component separation and placement of a subfascial biologic mesh are discussed.

Results: A successful resection of a piece of infected prosthetic mesh was performed with abdominal wall reconstruction. The patient was discharged on postoperative day 6.

Conclusion: Endoscopic component separation is technically feasible during the resection of infected prosthetic mesh and results in minimal postoperative wound morbidity.