Background: The use of the da Vinci® Surgical System, particularly the Xi version, allows to overcome some of the kinematic limitations of the direct manual laparoscopy in challenging procedures such as minimally invasive major hepatectomies. We herein present a case of left hepatectomy with regional lymphadenectomy for hepatocellular carcinoma with the use of the da Vinci® Xi. Methods: A 72-years old man with a long-lasting HBV chronic infection and CT scan and MRI finding of a 4-cm solid neoplasia of the left hepatic lobe and gallbladder stones, underwent surgery with the da Vinci® Xi platform. The patient was placed in a supine position, with 15