Introduction: We present the case of a 44-year-old male that came to the clinic with upper abdominal pain, EGD demonstrated a large infiltrative mass in the stomach. A biopsy was consistent with adenocarcinoma, tomographic imaging and endoscopic ultrasound staged the tumor as T2N3, stage 3. The patient underwent neoadjuvant chemotherapy and subsequently was scheduled for laparoscopic gastrectomy. Methods: The procedure consists of mobilization of the omentum at the level of the greater curvature and division of the gastroepiploic vessels. D2 Lymphadenectomy performed at the level of the hepatic artery, following by right crus dissection and completed circumferential mobilization of the esophagus. The next step is the transection of the esophagus at the level of EJ junction to perform an R-en-Y reconstruction with the closure of the posterior angle of the hiatus. The last step of the procedure was the creation of the jejunojejunostomy anastomosis using a linear stapler. Results: The procedure was completed without complications. Conclusions: D2 lymphadenectomy provides better survival benefits with better stating information.