We present a case of 78 year old male presented to emergency room complaining fever and weakness, initial workout shows elevated WBC, abdominal CT scan and ultrasound with changes of acute cholecystitis. Patient was taking to the operating room for a laparoscopic cholecystectomy with previous injection of indocyanine green for enhance view of the biliary tree. We described the intraoperative findings of severe acute cholecystitis with gangrenous gallbladder, large phlegmon area and the real utility of ICG view for safety dissection of the gallbladder in real time to decrease the chances of biliary injury and to complete the procedure. The patient underwent for laparoscopic cholecystectomy, a JP drain was left in the liver fossa and patient had an uneventful recovery, he was discharge two days after surgery and JP drain was removed one week later in the office.