Background: Adenocarcinoma of the gastrojejunostomy has been reported few times in literature. The laparoscopic management is challenging due to the reoperative nature of the procedure Methods: We present the case of a 79-year-old male with a history of open Billroth II gastrojejunostomy for ulcer disease 50 years ago, who now presented with adenocarcinoma at the anastomosis. After neo-adjuvant chemotherapy (imatinib) for three months, he was scheduled for laparoscopic resection. Results: Upon abdominal access, multiple adhesions were taken down from the colon, omentum and abdominal wall. The cavity was explored for metastatic disease, only to find a gastric serosa with small tumoral implants. Dissection was carried out on the lesser curvature and all lymph nodes were taken down. There was evidence of a retrocolic BII gastrojejunostomy. An omentectomy was performed. The stomach and hiatus were mobilized for the incision of the left diaphragmatic crus. The esophagus was distally divided at the gastrojejunal anastomosis. A standard D2 Lymphadenectomy was performed. A Roux limb was brought to the upper abdomen in an antecolic fashion for a side-to-side esophagojejunostomy. Eighty centimeters from the esophagojejunostomy, a side-to-side jejunojejunostomy of the biliopancreatic and alimentary limb was performed. Drainages were placed in the subhepatic space, specimen was retrieved, and the procedure ended with no immediate complications. Conclusions: Surgical therapy for redo gastric surgery for cancer is a safe and feasible curative treatment for adenocarcinomas of gastrointestinal anastomosis.