Laparoscopic splenectomy is a common procedure in patients with hereditary sperocytosis to decrease the transfusion requirements. After a splenectomy patients are at risk for post-splenectomy sepsis which has a significant mortality rate. Partial splenectomy has been demonstrated to achieve similiar beneficial effect on transfusion and may reduce adverse effect on the immune system. This child is a 2.5 year old female with hereditary spherocytosis. She had required 19 transfusions in the last 2 years and had asymptomatic gallstones. A laparoscopic cholecystectomy and partial splenectomy was performed. Following a laparoscopic cholecystectomy the spleen was mobilized with the plan to leave the residual spleen supplied by the short gastric vessels. Early hilar division and mobilization of the spleen allowed the spleen to be supported on the short gastric vessels. The spleen was then dissected in a non-anatomic manner to leave approximately 10 ml of splenic tissue. Postop course was uneventful. A liver-spleen scan demonstrated uptake in the LUQ at 2 months postop. At 1 year postop the child has not required any blood transfusions. Laparoscopic partial splenectomy can be safely performed and decreases short term transfusion requirements. Splenic function appears to be perserved.