We present the case and the recorded images of the extraction of a giant retroperitoneal cyst using a minimally invasive approach. Mesenteric and retroperitoneal cysts are rare and although the true incidence is unknown in the general population, it has been estimated at approximately 1/105,000 adult admissions to the hospital, most common in the fourth decade of life. The treatment of choice for retroperitoneal and mesenteric cyst is surgical enucleation. Marsupialization and aspiration are treatment options, however both are associated with higher rates of infection and recurrence. Our patient is an otherwise healthy 60-year old female with a six month history of increasing abdominal discomfort and distension. A computed tomography scan was obtained, which demonstrated the presence of the retroperitoneal cyst, which measured 27cm x 19cm x 27cm. She underwent laparoscopic removal as demonstrated. Intraoperatively her cyst was dissected free and the cyst fluid aspirated and sent for cytologic evaluation. The cyst was also explored laparoscopically and a portion of the cyst wall removed and sent for frozen section analysis prior to its removal through a 12 mm port. The patient's postoperative course was unremarkable and she was discharged on postoperative day 2 with improvement in her symptoms.