Peutz-Jehgers syndrome is a rare genetic disorder that is characterized by diffuse gastrointestinal hamartomatous polyposis. We present an unusual de novo case of Peutz-Jehgers syndrome in which a young woman presents with subacute right lower quadrant abdominal pain. A CAT scan performed as the initial diagnositic modality revealed an ileocolic intussuseption and several colonic polyps. Further evaluation revealed diffuse small and large bowel hamartomas as well as a chronic, non-reducing, partially obstructing ileocolic intussuseption. This video demonstrates a unique one stage management option whereby her intussuseption and enterocolic polyp burden was managed in a single procedure using a combined laparoscopic and endoscopic approach. Initially, a laparoscopic assisted ileocolic resection of the chronic intussuseption was perfomed using a 3 port technique. Then, prior to creation of the anastomosis, the entire small and large intestine were lumenally surveyed with intraoperative enteroscopy and colonoscopy via the open ends of bowel. Endoscopic polypectomies were liberally performed to clear the bowel of all significant polyp burden. In summary, this case demonstrates a multimodal technique to manage several pathologic processes spanning the entire gastrointestinal tract of a patient with Peutz-Jehgers syndrome.