Crohn's disease is a chronic inflammatory condition of unknown cause that may involve any part of the gastrointestinal tract from the mouth to the anus, causing scarring and thickening of the bowel wall leading to abscess and fistula. The terminal ileum is involved in up to 75% of patients with this affliction. When surgery is indicated, conservative resections are performed in the desire to preserve as much small bowel as possible, since the natural course of the disease is such that at least 50% of patients treated surgically will require reoperation at a later date. Laparoscopic resection is being employed with increasing frequency in Crohn's disease, and is considered the preferred operative approach by some authors. Standard laparoscopic approaches to ileocecal resection involve use of 4 to 5 ports and a three person operative team. We have modified the medial to lateral approach to the ileum and cecum such that the dissection, in most cases, can be accomplished with only 3 ports, a surgeon and a camera holder. There are no disadvantages to this approach as the remaining ports may be added if needed. The purpose of this video presentation is to display the technique, and the modified sequence of dissection. Illustrations are incorporated in the video to facilitate comprehension. A typical Crohn's terminal ileitis is shown and the successive steps to perform the resection of the terminal ileum and cecum are described. Dissection, exteriorization, division and ligation of the mesentery, excision, and anastomosis are shown.