Laparoscopic adrenalectomy is now the gold standard for a variety of adrenal pathologies including pheochromocytomas, functional cortical tumors and non-functional tumors. Controversy still exists about laparoscopic approach for large tumors and for primary malignancies of adrenal gland. We present two elderly patients (octogenarians) who underwent a laparoscopic adrenalectomy for large adrenal metastases from lung and breast carcinomas. Both patients had a very short postoperative length of stay (two days) and an uneventful postoperative course. The final pathology confirmed an adrenal metastasis from lung cancer in our first patient but revealed a primary adrenal cortical adenocarcinoma in the second one. Laparoscopic adrenalectomy offers the advantages of minimally invasive approach with diminution of postoperative pain, very short postoperative length of stay and improved cosmesis. The video shows that even very large tumor can be excised safely through a laparoscopic approach. There should be no absolute contraindications to a laparoscopic approach to adrenalectomy regarding size or histology as it is possible to perform the same dissection as would be done in an open approach. Large size tumor and malignant histology are nonetheless characteristics that may predict a long and tedious laparoscopic dissection.