Leakage of pancreaticojejunostomy represent the main technical post-operative complication after pancreaticoduodenectomy. Because pancreatic fistula can be the source of morbidity and mortality and it is related to the integrity of the pancreatic-enteric anastomosis, a number of technical modifications have been suggested, including pancreaticojejunostomy, pancreaticogastrostomy and occlusion of the main pancreatic duct with fibrin glue. The incidence of leakage is particularly high in case of narrow ducts and a tender pancreatic glands; in such conditions some experiences in literature suggest a technique of occlusion of the main pancreatic duct with fibrin glue. We present a case of a 50 year old man with sudden appearance of jaundice, weight loss and itch. A CT scan of the abdomen did not show any mass but only a dilatation of biliary ducts. ERCP disclosed a malignant stenosis of the distal bile duct. Microscopic examination of biliary biopsy specimens revealed a picture of carcinoma of bile duct. We performed a pylorus preserving pancreaticoduodenectomy with fibrin glue occlusion of the main pancreatic duct. The post-operative course was uneventful; the patient received a chemotherapic treatment for six months and is still alive and in good health after 18 months.