Our patient is a 52-year-old otherwise healthy woman who was diagnosed with K-ras wild-type, synchronous stage 4 transverse colon cancer with bulky, bilobar liver metastatic disease. She underwent 13 rounds of chemotherapy with FOLFIRI and bvacizumab and enjoyed a robust response, making her amenable for curative resection. She was taken to the operating room for an exploratory laparotomy, right hepatectomy, a left partial segment II hepatectomy and an extended right hemicolectomy. She recovered without complication and resumed adjuvant chemotherapy. Unfortunately, she was found to have a solitary recurrence in the left lateral sector within the year postoperatively. Given her prior right hepatectomy and presumed hepatic parenchymal injury after extensive oxaliplatin-based chemotherapy, she was at high risk for hepatic insufficiency postoperatively. Her pre-operative liver function was normal and she was taken to the operating room for a left lateral sectionectomy. In order to achieve an oncological sound parenchymal-sparing resection, robotic assistance with near-infrared fluorescence technology (NIRF) with indocyanine green (ICG) was used. ICG highlights perfused hepatic parenchyma and facilitated our intraoperative dissection to preserve maximal viable liver tissue. In addition, we maintained our dissection plane in poorly vascularized parenchyma, thus minimizing blood loss. The patient tolerated the procedure well and maintained normal hepatic function postoperatively. This case demonstrates the safety and efficacy of intraoperative NIRF with ICG to achieve an oncologic resection while preserving parenchyma in a patient with limited hepatic reserve.