A previously healthy male, born at 35 weeks gestational age, presented with a prenatally diagnosed intra-abdominal cyst, most likely representing a duplication cyst. After birth, two repeat ultrasound studies confirmed the presence of a cyst and described it as a cystic lesion in the midline of the abdomen, anterior to the pancreas and medial to the left lobe of the liver and the gallbladder, measuring 2x2x2cm. It appeared to demonstrate bowel signature and was suspicious for a duplication cyst. At 7 months, the patient was brought to the operating room and placed under general anesthesia. The abdomen was prepped with Chloraprep, and a dose of Ancef was administered. One 5 mm step trocar was placed in the umbilicus. Two additional stab incisions for 3 mm instruments were placed in the right and left abdomen. Upon inspection, it became clear the cyst was associated with the first portion of the duodenum. The seromuscular layer was divided and the mucosa of the cyst was dissected away from the bowel. The cyst was dissected off the bowel intact, without violating the underlying mucosa. The seromuscular defect was closed with interrupted 4-0 Vicryl sutures. The instruments were removed and the fascia of the umbilicus was closed with 3-0 Vicryl, and skin was closed with 5-0 Monocryl. The patient's post-operative course was uncomplicated, and he was discharged home on post-operative day 2.